Epithalon

Epithalon is a synthetic tetrapeptide with the amino acid sequence Alanine-Glutamic Acid-Aspartic Acid-Glycine (Ala-Glu-Asp-Gly).

Originally developed by Russian gerontologist Vladimir Khavinson and derived from the natural pineal gland extract Epithalamin, it is studied for its potential role in healthy aging and longevity.

Key mechanisms and effects include:

• Telomere Maintenance: It activates telomerase, an enzyme that repairs and lengthens telomeres, potentially slowing cellular aging and extending the replicative lifespan of human somatic cells in vitro.
• Circadian Regulation: It supports the pineal gland’s function, helping to restore melatonin production and stabilize circadian rhythms, particularly in older adults.
• Antioxidant and Immune Support: It reduces oxidative stress and may modulate immune function and gene expression related to stress resistance.