Humanin

Humanin is a 24-amino acid mitochondrial-derived peptide(MDP) that functions as a cytoprotective and neuroprotective agent, primarily by inhibiting apoptosis(programmed cell death) and reducing oxidative stress.

Research indicates that Humanin offers significant benefits in longevity and healthspan, with studies showing it can increase lifespan by 12% and reduce age-related pathologies by 25% in animal models.

Key therapeutic benefits supported by preclinical and early research include:

• Neuroprotection: It protects neurons from amyloid-beta toxicity and tau pathology, offering potential treatment avenues for Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative conditions by preserving neuronal survival and reducing synaptic loss by up to 40%.
• Metabolic Regulation: Humanin enhances insulin sensitivity and glucose tolerance, helping to prevent beta-cell dysfunction and potentially reducing the risk of metabolic syndrome and type 2 diabetes by improving mitochondrial function.
• Cardiovascular and Anti-Inflammatory Effects: The peptide stabilizes mitochondrial function in heart tissue, reduces pro-inflammatory cytokines (such as IL-6 and TNF-α) by 25-50%, and protects against ischemia-reperfusion injury in organs like the heart and brain.
• Longevity Association: Circulating Humanin levels naturally decline with age but remain stable in long-lived species like the naked mole-rat and are significantly higher in children of centenarians, suggesting a strong link to healthy aging.